During her hospitalization the patient manifested leukocytosis to 47,000 WBC/<i>μ</i>L, ESR 67 mm/hr (normal range 0-42 mm/hr), CRP 17.5 mg/dL (normal range 0.02-1.20 mg/dL), and microangiopathic haemolytic anemia, with declining haemoglobin and haematocrit. The gene discussed is CRP; the disease is Increased total leukocyte count.