We and our collaborators found that MMP-7 nuclear translocation and stability requires ARF-mediated tumor microenvironment for cell migration by disruption of cell adhesions.16 Co-overexpression of MMP-7 and ARF resulted in greater cell migration, whereas knockdown of MMP-7 decreased wound healing ability of cells in prostate cancer.16 Thus nuclear MMPs may promote cell migration greater than extracellular MMPs. The gene discussed is CDKN2A; the disease is prostate carcinoma.