Nuclear MMP-3 is associated with tissue remodeling and cancer progression.39 In addition, constant expression of MMP-3 may lead to severe damage of nuclear matrix and the formation of genetic abnormalities.39 In recent studies, Sun et al. 39 reported that Bmi-1 induces expression of MMP-3 through NF-κB signaling pathway, which has implication in the progression of glioma. This evidence concerns the gene MMP3 and central nervous system cancer.