Studies have shown that overexpression of MMP-13 plays a role in the metastasis of colon cancer, breast and other cancer types.24–27,31–33 For instance, disruption of basement membranes of tissues by upregulated MMP-13 leads to cell dissociation, tumor invasion and metastasis in breast cancer.33 MMP-10 was known to induce cell invasion in cervical tumors. This evidence concerns the gene MMP13 and colonic neoplasm.