In fact, a decreased TEER has been found in biopsy specimens from patients with chronic rhinosinusitis with nasal polyps along with an irregular, patchy, and decreased expression of the tight junctions molecules occludin and zonula occludens 1 [15], thus suggesting the beneficial role of products of Rhinosectan® with the capacity of increase TEER values. This evidence concerns the gene OCLN and chronic rhinosinusitis.