Achieving stable blood glucose levels and adequate hemoglobin A1c (HbA1c)and preventing the development of micro vascular and macro vascular complications are the main goals of treatment in T1DM.5,6 The Diabetes Control and Complications Trial has shown that intensive insulin regimens to reduce glucose to near-normal levels are associated with delays in incidence and progression of diabetes-related complications.3,4,7. The gene discussed is INS; the disease is type 1 diabetes mellitus.