Intensive insulin therapy is also associated with increased risk of hypoglycemia, and weight gain.3 Thus the goals of good glycemic control are often not achievable.8 Physiologic changes in insulin sensitivity during growth and pubertal development also results in insulin resistance in both adult and youth with T1DM.9 In addition to glycemic control, patients with T1DM do not meet the targets of metabolic control for BMI, blood pressure, low-density lipoprotein (LDL)-cholesterol, and triglycerides.2,10,11. The gene discussed is INS; the disease is type 1 diabetes mellitus.