Lifestyle intervention to address these factors appears to be a valuable part of any therapeutic approach.8 A positive impact of mild to moderate exercise intervention on IR in young patients has been reported.9 The current study (Trial No: (Trial ID ISRCTN16466697) was designed to determine the effects of a 25 weeks supervised structured aerobic exercise training (SSAET) program on fasting blood glucose level (FBGL), plasma insulin level (PIL), glycemic control (GC), and insulin resistance (IR) in type 2 diabetes mellitus (T2DM). Here, INS is linked to Insulin resistance.