INS and obesity due to melanocortin 4 receptor deficiency: High resistance to insulin-stimulated glucose uptake and hyperinsulinemia increase the possibility of three major interrelated diseases including T2DM, hypertension and coronary artery disease (CAD).3 Obesity is one of the key risk factors which increase the possibility of IR and T2DM due to increased secretions of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors from the adipose tissues in obese person’s body.