INS and obesity due to melanocortin 4 receptor deficiency: The long and short term physical inactivity causes metabolic and vascular changes, which lead towards IR and ultimately to T2DM.5 A vigorous and non-vigorous physical activity programs produced positive impacts on insulin sensitivity and reduction in IR in mild to moderate type of T2DM patients and supports the recommendation of moderate physical activity in patients with impaired glucose tolerance and T2DM.6 Ageing has no correlation with the development of IR, while physical inactivity and obesity has a direct relation with IR occurrence.7