WNK2 and breast cancer: STMN1 was also shown to be activated by the Ras-mitogen-activated protein kinase and hedgehog signaling pathway in some studies.21 Researchers observed thiostrepton got over to TBR by blocking transition from G1 to S phase in cell lines.22 Treatment with low-dose anti-STHMN1 therapy and taxane was shown to halt tumor invasion in a breast cancer xenograft.23