CFTR and hereditary disease: Cystic fibrosis (CF) is life limiting genetic disorder common in Caucasians of North America, Australia and Europe.1,2 Mutated CF transmembrane conductance regulator (CFTR) epithelial chloride channel desiccates secretions in respiratory airways, hepatobiliary-pancreatic ducts and in other tissue linings, resulting in gradual and persistent organ damage.3 Estimated gene frequency of cystic fibrosis varies in different ethnic groups with highest incidence in Caucasians (1 in 2,500).