Given the potential of other VDR SNPs (Taq-I, Bsm-I, Apa-I) to influence the stability of VDR mRNA herein, we aim to evaluate the effects of vitamin D supplementation according to four different VDR SNPs (Taq-I, Bsm-I, Apa-I and Fok-I) on glycemic and lipid responses in T2DM patients. Here, VDR is linked to type 2 diabetes mellitus.