Male β2GPI−/− mice developed severe septicaemia earlier than male WT mice within 24 h following an intravenous injection of E. coli (at 24 h male β2GPI−/− 71.4% vs male WT 28.6%, had a severity score of ≥ 3, p < 0.03, n = 7) (Fig. 1). Here, APOH is linked to bacterial infectious disease with sepsis.