GJA1 and metabolic dysfunction-associated steatohepatitis: For this reason, the present study was set up, in which NASH mice were treated with Gap24 or Gap19 coupled to a transactivator of transcription (TAT) sequence, being peptides that act as specific inhibitors of hemichannels consisting of Cx32 and Cx43, respectively, while leaving their full gap junction channel counterparts unaffected12.