CDKN1B and atherosclerosis: The importance of p27 expression in regulating neointima hyperplasia, including atherosclerosis and restenosis, has been well-established in previous studies, which have demonstrated the effects of DES containing rapamycin in the suppression of restenosis following angioplasty36 and the attenuation of neointimal hyperplasia by the transfer of the p27 gene35.