Again, hypertension and diabetes mellitus both type-1 and type-2 are reported to be the major risk factors for the genesis of atherosclerosis21, The development of T1DM due to both increased DCN-2 level and DCN-2 induced inhibition of NO and insulin synthesis might promote prothrombotic condition that leads to atherosclerosis. This evidence concerns the gene INS and type 1 diabetes mellitus.