Given that both the imaging modalities have their own advantages and limitations, and can provide a range of complementary information, some similar (for example haemoglobin content and blood oxygenation) and some unique (for example, MRI apparent diffusion coefficient values related to tissue cell density), a carefully planned imaging approach dependent on the nature, location and spread of the disease, should permit the selection of either one or both modalities to image the changes in melanoma cell re-differentiation following BRAF or Hsp90 inhibition. This evidence concerns the gene BRAF and melanoma.