This end-stage chronic kidney disease was characterized by enhanced body weight, increased BUN levels, glomerular IgG deposits, sclerotic glomeruli, fibrosis, and kidney interstitial infiltration by CD11b + , F4/80 + and CD3 + cells and increased expression of mRNA coding for proinflammatory cytokines (Supplementary Fig. 9a–e). This evidence concerns the gene ITGAM and chronic kidney disease.