To investigate the potential regulatory function of PtpA in tumor progression in vivo, we used a mouse xenograft model using A549 cells infected with WT BCG, BCG (ΔPtpA + PtpA), BCG ΔPtpA, BCG (ΔPtpA + D126A), or BCG (ΔPtpA + PtpA Δ1-20) strain. This evidence concerns the gene PTPA and neoplasm.