To explore the mechanism of HOXD-AS1 upregulation in HCC, we applied online bioinformatical software programs JASPAR (http://jaspar.genereg.net/cgi-bin/jaspar_db.pl) to analyze promoter region of HOXD-AS1 and 13 potential sites of STAT3 binding were found. Here, HAGLR is linked to hepatocellular carcinoma.