The expression of Girdin is upregulated in multiple malignant tumors, such as colon cancer, glioma, and breast cancer [27–29], promoting carcinogenesis and development, invasion and metastasis, angiogenesis and autophagy, and leading to poor prognosis for patients [24, 25, 27, 29, 30]. Here, CCDC88A is linked to malignant colon neoplasm.