Two patients developed clinical features consistent with a microangiopathic hemolytic anemia (MAHA) syndrome with proteinuria, hemolytic anemia, low haptoglobin, thrombocytopenia, and serum creatinine increase, 4 weeks after pazopanib initiation and 2 weeks after the first bevacizumab infusion. Here, HP is linked to congenital thrombotic thrombocytopenic purpura.