In summary, blocking IL-10 signalling at the time of immunization increases the numbers of IL-10 producing T cells; does not induce unwanted side effects, especially in the intestine of the immunized mice therefore this immunisation strategy may be effective against HPV chronic infection and HPV infection related cancers, with minimal chance of increasing the incidence of autoimmune diseases of immunized patients. This evidence concerns the gene IL10 and chronic human papillomavirus infection.