Because Cx46 and Cx50 levels are similarly reduced at 1 and 2 months of age, lens gap junctional conductance in 1-month-old Cx46fs380 heterozygous and homozygous mice is expected to be comparably decreased as at 2 months of age (i.e., before cataracts are evident in homozygotes). Here, GJA8 is linked to cataract.