CLK1 and non-small cell lung carcinoma: Altogether, our data indicate that the diagnostic TEP RNA profiles may be caused by (1) altered megakaryocytic RNA expression, (2) enrichment of reticulated platelets in patients with NSCLC (Dymicka-Piekarska and Kemona, 2008, Stone et al., 2012), (3) induction of splicing, possibly partially mediated by RBP activity and upstream regulatory kinases such as Clk (Denis et al., 2005, Schwertz et al., 2006), (4) sequestration of RNAs (Nilsson et al., 2011, Nilsson et al., 2015), and (5) alternative splicing events.