ACE and metastatic neoplasm: Thus, lower ACE activity was observed in serum from patients with high grades (G1/G2 717.38 ± 187.94 vs G3/G4 634,5 ± 192,592; Mann-U p = 0.029) and metastatic CCRCC (local disease 706,1 ± 192,81 vs metastatic disease 565.18 ± 147.05; Mann-U p = 0.009).