SERPINA3 and schizophrenia: Although enrichment analysis of schizophrenia subtypes only showed upregulation of the 'immune response' pathway in undifferentiated and paranoid schizophrenia, we found that most differentially expressed genes involved in 'immune response', 'inflammatory response' and 'MHC class I receptor activity' pathways, including IFITM1, IFITM2, IFITM3 and SERPINA3, are overexpressed in all three subtypes (Figure 1 and Supplementary Figures S3 and 4), suggesting that the activation of the immune system may be a common denominator in diverse subtypes of schizophrenia.