Among those, 25 genes were identified by all three methods, including HBA1, HBA2, HBB and IFITM1, all of which have been reported to be differentially expressed in previous transcriptome studies in schizophrenia (Figures 1 and 2 and Supplementary Table S3).15, 17, 33 Several other and more highly differentially expressed genes showed significant P-values by one or two methods—all supported by previous studies. This evidence concerns the gene HBB and schizophrenia.