For example, genes involved in the neuregulin 1–ErbB4 signaling pathway, including DOCK7, EGFR, PTPRZ1 and the key regulator ERBB4,45, 46, 47 were downregulated in undifferentiated and disorganized schizophrenia, while they were upregulated in paranoid schizophrenia (Supplementary Figure S7). Here, NRG1 is linked to schizophrenia.