Notably, several GABAergic genes, which exhibited reduced expression in the prefrontal cortex of subjects with schizophrenia, were uncovered in our study, including NPY, SST and RELN. 34, 35, 36, 37 Moreover, expression levels of genes involved in dopaminergic transmission, such as CNR1, HTR2A, HTR2C, NR4A2, NTSR1, NXPH3 and SLC17A8, were also reduced (Supplementary Table S4).38, 39, 40, 41, 42, 43. This evidence concerns the gene CNR1 and schizophrenia.