In view of these results they proposed that the increase in serum vaspin concentrations found in patients with type 2 diabetes, normal or impaired glucose tolerance, in their previous study [43] either suggested that patients had unrecognized antioxidant supplementation and thus increased oxidative stress induced by exercise did not take place, or that the training intensity in this previous study was not sufficient to chronically increase oxidative stress. This evidence concerns the gene SERPINA12 and type 2 diabetes mellitus.