For instance, Malik et al. [11] provided new evidence about the role of ERE sequences in the regulation of a E2-dependent gene, Reprimo (RPRM), whose activation of the E2/ERα complex induces the recruitment of other molecules, such as FoxA1 and HDAC7, causing a transcriptional silencing in a model of a BC cell line. The gene discussed is RPRM; the disease is breast cancer.