It is known that pathogenic CD4+ T cells for the transfer EAE express cytokines including IFN-γ, IL-17A, and IL-6 (Langrish et al., 2005), and very strong stress alone induces gastric disease via p38 activation at the affected tissues by the activation of the vagal pathway (Debas and Carvajal, 1994; Jia et al., 2007; Uwada et al., 2017). The gene discussed is CD4; the disease is stomach disorder.