We showed that the injection of IFN-γ, IL-17A, and IL-6 or ATP at specific vessels in the brain of mice with relatively low stress establishes a neural pathway via DMH and DMX (nucleus of vagal nerves) followed by the development of fatal gastrointestinal diseases (Figures 4G and 5G) and the activation of p38 in stomach (Figure 2—figure supplement 1). This evidence concerns the gene IFNG and gastrointestinal disease.