A recent study by Benlloch et al. reported that PT treatment suppressed the anti-oxidative properties of melanoma and pancreatic cancer cells via downregulation of GSH and glucocorticoid levels, and inhibition of glucocorticoid receptor and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent antioxidant defense system16. This evidence concerns the gene NFE2L2 and melanoma.