Therefore a specific PET radiotracer for MCHR1 imaging is of high scientific interest, since it comprises several advantages for clinical medicine and biomedical research, such as monitoring of the hormone receptor status and related pathologies in-vivo, compound dose selection and the in vivo quantification of the MCHR1 as a risk factor and early diagnostic tool for adiposity, diabetes and insulin resistance. Here, MCHR1 is linked to Insulin resistance.