Strikingly, the transcriptional signature of AsPC1-AKT tumors originating from either lean or obese mice significantly overlapped with that of Obese-CFP, when compared to Lean-CFP tumors (Supplementary Fig. 8f), suggesting that enhanced in vivo tumor growth is a strong inducer of nitrogen metabolism and the urea cycle. This evidence concerns the gene AKT1 and neoplasm.