AKT1 and obesity due to melanocortin 4 receptor deficiency: Notably, independent of obesity, the volumes of AsPC1-AKT tumors (Lean-AKT and Obese-AKT) were comparable to those of Obese-CFP tumors and 1.6-fold larger than those of Lean-CFP (~170 versus 105 mm3, P ≤ 0.01 by one-way ANOVA followed by Tukey test, compare Figs. 6b and 1c).