Furthermore, ARG2 knockdown strongly and specifically suppressed 15N-ornithine production in PDA tumors of obese, compared with lean mice (M1, P ≤ 0.05 and M2, P ≤ 0.01, one-way ANOVA followed by Tukey test, Fig. 4d). This evidence concerns the gene ARG2 and Patent ductus arteriosus.