Accordingly, we hypothesized that combination of anti-GITR antibody (Ab) that enhances the number of effector CD4+ and CD8 T+ cells with immunotherapies that inhibit suppressive cells such as Tregs or myeloid-derived suppressor cells (MDSCs) will synergize to lead to a potent anti-tumor effect. This evidence concerns the gene TNFRSF18 and neoplasm.