In contrast to vasopressin and terlipressin, selepressin does not activate the vasopressin V2 receptors that are mediating antidiuretic effects [16], release of von Willebrand factor [16, 17], and vasodilation by stimulation of nitric oxide production [18, 19], all of which might be harmful during septic shock due to exacerbation of oliguria, procoagulation, and vasodilation. Here, AVPR2 is linked to Shock.