CD274 and neoplasm: Based on data available at the time [confirmed ORR = 13.3% and 16.1% at minimum follow-up of 13 weeks (n = 226) and 6 months (n = 161), respectively; median duration of response not reached in either group; no difference in response ate based on PD-L1 tumor expression in the 84% of patients who were evaluable] avelumab received accelerated approval for patients with locally advanced or metastatic urothelial carcinoma whose disease progressed during or following platinum-containing chemotherapy, or within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy [68].