To identify suitable reference genes during T-cell lymphoma development, we investigated the expression stabilities of eight commonly used candidate reference genes (Gapdh, Rn18s, Actb, Hprt, B2M, Rplp0, Gusb, and Ctbp1) by RT-qPCR at different time points following the administration of MNU. Here, CTBP1 is linked to T-cell non-Hodgkin lymphoma.