A recent study showed that MEK inhibition reduces accumulation of mMDSC (CD11b+ MHCII− Ly6Chi cells) in tumor-bearing mice [15], however, in combination with adoptive cell-therapy, MEK inhibition had no effect on mMDSC levels in tumors of a SM1 mouse melanoma model, but instead, decreased granulocytic-MDSCs (gMDSC, CD11b+ Ly6G+ Ly6C+ cells) [9]. This evidence concerns the gene ITGAM and neoplasm.