Hence, this slight increase in workload may be inevitable in obtaining safe and effective blood glucose control, especially in the initial phase, aiming for a short time to reach the chosen target range combined with a high time-in-target range, low glucose variability, and avoidance of hypoglycemia, and this in a setting with rapid changes in patients insulin sensitivity and in the presence of external confounding factors such as use of steroids and parenteral nutrition. Here, INS is linked to Hypoglycemia.