These genes include the well-known ALL genes ETV6, RUNX1, KMT2A, and PAX5 that form fusion genes with up to five different partners; the emerging BCP-ALL subgroup defined by ZNF384 rearrangements; and the new P2RY8, PDGFA, and PDGFRA nodes. The gene discussed is P2RY8; the disease is acute lymphoblastic leukemia.