Deletions involving several of the highly differentiated genes in this region have been suggested to contribute to MDS, including PAFAH1B1 (the primary lissencephaly-related gene, also known as LIS1, CFA9:46,647,994–46,727,422), MNT (CFA9:46,466,709–46,482,614) and SMG6 (CFA9:46,161,531–46,405,748) [56–58]. Here, SMG6 is linked to lissencephaly spectrum disorders.