In addition to effective reduction in parameters such as body weight, body mass index, obesity degree or waist/hip ratio, many clinical trials show that acupuncture treatment can improve obesity-related complications, including dyslipidemia, inflammation, and plasma leptin concentration, suggesting that acupuncture is a safe and effective therapy for patients with obesity [8–12]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.