For example, complement and coagulation cascades (e.g., C1ra, C7, Thbd, Serpina1b, C3, C4b, Serpina1d, Serping1, Serpina1e, C1s, Cfd, Plau), cytokine-cytokine receptor interaction (e.g., Ccl11, Amhr2, Lep, Ccl24, Ccl9, Ccl8, Pf4, Fifg, Gm1987, Prl, Ghr, Ccl6), and systemic lupus erythematosus (e.g., C1ra, C7, C3, C4b, Hist2h2ac, H2-eb1, H2-aa, H2-ab1, C1s, Hist2h2aa1) were increased in the Stat5NKO group and were reversed by EA treatment. The gene discussed is C4B; the disease is systemic lupus erythematosus.