LEP and obesity due to melanocortin 4 receptor deficiency: Moreover, based on the top 50 DEG list, 41 common genes whose expression levels were up-regulated in the Stat5NKO group were dramatically decreased after EA treatment, and most of these genes were closely related to the development of obesity, such as Gh, Prl, Lep, Igfals, Plin1, Agpat2, Mogat2, and Cidec (S6 Table).