Most autophagy inducers that have been tested are based on inhibiting the autophagy suppressor mTOR, such as the well-known mTOR inhibitor rapamycin [21, 52, 53], which seems to be effective to decrease Aβ levels and prevent cognitive impairment in AD mice when used at early stages prior to the formation of extracellular plaques. This evidence concerns the gene MTOR and Cognitive impairment.