We report that proliferative PαC in hypertrophied muscularis from intestinal partial obstruction models and diseased human GI tissue (colorectal cancer tissue, Crohn’s disease small intestine, and diverticulitis colon) overexpress CACNA1G, the same T-type Ca2+ channels driving the growth of colon cancer cells, suggesting the Ca2+ channels may also induce proliferation of PαC. Here, CACNA1G is linked to diverticulitis of colon.