SAA1 and Disseminated intravascular coagulation: The higher expression of ICAM-1 has been linked to the systematic injuries of vascular endothelial cells in the LPS stimulated disseminated intravascular coagulation (DIC) mice model [15], and SAA-1 was found to disturb the balance of endothelial tissue factor pathway, which acts as a component of initiation of coagulation cascade [16].