Interestingly, no renal defects were observed in mice with constitutive endothelium-specific deficiency of Gpr116 and Eltd1 (S6 Fig), indicating that loss of Gpr116 and/or Eltd1 in endothelial cells is not responsible for the glomerulopathy observed in global dKO mice. The gene discussed is ADGRF5; the disease is lipoprotein glomerulopathy.