Reduced risk of HPV18-associated cervical cancer was seen with HLA Class II alleles (HLA-DRB1*13 (OR = 0.51, P = 0.0058), HLA-DQB1*0603 (OR = 0.42, P = 0.021) and HLA-DQA1*0103 (OR = 0.50, P = 0.041)). The gene discussed is HLA-DQB1; the disease is cervical carcinoma.