For example, both the histone H3 lysine 9 methyltransferase SETDB1 [7] and the transcription factor SOX10 [8] accelerate melanoma onset when coexpressed with BRAFV600E in a tp53 mutant line, whereas overexpression of HEXIM1 in this system suppresses tumour formation [9]. Here, SETDB1 is linked to melanoma.