We looked specifically at the 13 significantly mutated genes in human cutaneous melanomas identified by The Cancer Genome Atlas, as well as HRAS and KRAS which were used to categorise the samples and also GNAQ, GNA11, KIT, CTNNB1 and EZH2 which were found to carry mutations at low frequencies in the triple wild-type set of melanomas [36]. The gene discussed is CTNNB1; the disease is melanoma.