The density of cells was significantly greater, and the arrangement of hepatocytes was disrupted more in the livers of mice inoculated with Ba/F3 cells expressing NPM-ALK than in the livers of mice inoculated with control Ba/F3 cells and Ba/F3 cells expressing the kinase dead mutant of NPM-ALK (K210R) (Fig 6C), suggesting that these differences were due to the infiltration of NPM-ALK-induced tumor cells. This evidence concerns the gene ALK and neoplasm.