HMOX1 and neoplasm: Besides the mentioned effect on proliferation and migration, a high expression of Nrf2 also leads to reduced apoptosis rates37 and autophagy.38 Furthermore, there are evidences that Nrf2 promotes angiogenesis by activating heme oxygenase 1, which itself takes part in the process of angiogenesis.39 In addition, it has already been shown that Nrf2 regulates xCT.40 Therefore, it seems likely that at least a part of the effect of Nrf2 on tumor cells is caused by elevated xCT.