ACTH inhibits death of OL and OPC induced by several mechanisms that are involved in damage to the CNS in MS as well as other disorders of the CNS, including glutamate (excitotoxicity) [96,97], apoptosis (induced by staurosporine, a widely employed molecule in apoptosis research) [96,97], reactive oxygen species (ROS) induced by hydrogen peroxide (H2O2) [96,97] and inflammation mediated by quinolinic acid (QA), a product downstream of kynurenic acid in the tryptophan indoleamine pathway [96,97] (Table 1). Here, POMC is linked to myeloid sarcoma.