The common genetically engineered models of pancreatic cancer are based on Kras mutations and also include PDX-1-Cre/Lox-Stop-Lox (LSL)-Kras or p48/LSL-Kras mice, which have been modified by deletions or mutations of Ink4, p53, Mist, Smad4 or TGF-β [118,119,120]. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.