Therefore, if we could increase the [Cl−]i by elevating the NCC- and/or NKCC-mediated Cl− uptake, the insufficiency of insulin secretion would be improved via membrane depolarization due to elevation of Cl− efflux from pancreatic β cells of ΔF508 CFTR-expressing CF patients. The gene discussed is CFTR; the disease is cystic fibrosis.