Moreover, EML4-ALK, the most common ALK fusion found in NSCLC, is formed by an inversion occurring on the short arm of chromosome 2 involving the genes encoding ALK (2p23) and EML4 (2p21) with variants 1, 2, and 3a/3b being the most frequent fusion patterns [25,26]. Here, EML4 is linked to non-small cell lung carcinoma.